PRF is the most upgraded version of PRP!
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PRF-PRP (Growth factors) regenerative medicine at the service of beauty

PRF is one of the top anti-aging treatments! It dramatically reduces] wrinkles, enhances firmness and treats laxity, smooths out acne marks and scars! All this, with only a small amount of your blood!

PRF -PRP
Treatment identity

Basic information

Treatment duration: PRF preparation and application requires about10’

Return to your activities: Immediately.

Pain: Tolerable, as it is caused by mild pricks.

Anesthesia: Anesthetic cream.

Side effects: Mild redness for the first 24 hours. There is a possibility for limited ecchymosis (bruises) to be caused.

Recovery period: Not required.

Number of sessions required per treatment cycle: 2-6 treatments depending on the pre-existing condition of the tissues.

The effects are visible: 7-10 days after the session.

Duration of effects: About 1 year, after the completion of the session cycle.
PRP - PRF
What is PRF and how it works
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PRF is the upgraded version of PRP

PRF (platelet-rich fibrin), as its name describes, is a fibrous material highly rich in platelets; as a result, it offers impressive effects of a completely natural rejuvenation and healing of the skin.
In essence, it is the highly upgraded version of Autologous PRP Mesotherapy. PRF is a 100% natural treatment, as it results from the special processing of the patient's blood.

After the short blood draw, the blood sample is placed on a special device where it is centrifuged at specified spins, for a specific time. At the end of the procedure, in the upper and lower parts of the vial, the platelet poor plasma and red blood cells have accumulated respectively and are discarded. PRF is in the middle of the vial; it is the only one we aspirate to inject it into the areas where the patient wishes the treatment to be performed.

PRF can be performed on the face, the neck, the neckline, the back of the hands, on any part of the skin where it can offer a solution to a problem.
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PRP - PRF
Main differences of PRP and PRF
The main differences between PRF and PRP, which highlight the superiority of PRF, are the following:

1.    Centrifugation

PRP: The patient’s blood is centrifuged at a high speed, completely separating the plasma layer.

PRF: The blood is centrifuged at a lower speed; as a result, a fibrin mesh is formed (something that does not happen in PRP), in which platelets, leukocytes, and stem cells are “trapped”. This fibrin mesh slows down and prolongs the release of growth factors, compared to PRP.

2.    Increased platelet concentration


In PRF, slow rotation also means that fewer cells are destroyed, leaving a higher concentration of therapeutic platelets. This leads to increased concentration of growth factors, after the activation of platelets.

PRF: Contains about 10 times the platelet concentration of the body.

PRP: Contains about 2-5 times the platelet concentration of the body.
3.    Use of anticoagulants or other components

PRP: The patient’s blood is collected in vials containing anticoagulants (usually sodium citrate), which prevent blood clotting during injection. Anticoagulant agents prevent the formation of a fibrin mesh; that’s why the release of growth factors is more immediate at PRP. Furthermore, for the preparation PRP the use of activators, such as calcium chloride, is required. These substances are reinjected into the patient, with potential consequences due to their antigenicity.

PRF: It is 100% natural treatment. No anticoagulants or other components are used. Apart from eliminating the possibility of causing an allergic reaction, the absence of heterologous components fosters the creation of fibrin mesh, which causes the sloewer release of growth factors.  

4.    Release of Growth Factors


PRP: It releases growth factors for a few hours.

PRF: As described above, PRF releases growth factors for up to a week after the treatment. The more successful and long-lasting effects of PRF compared to PRP, are due to this release, as, in this way, clearly more growth factors are consumed.
PRF -PRP
PRF: what it offers to the skin
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1.    Enhances collagen production

PRF injections can stimulate collagen production, which is decreased over the years, causing skin laxity, blur and dehydration. PRF restores these problems.

2.    Eliminates wrinkles and fine lines on the skin

PRF provides high concentration of platelets and fibrin at the areas where it is injected. That causes natural tissue regeneration and healing, which helps to eliminate all types of facial wrinkles, fine lines and folds.

3.    Significantly helps treat dark circles and under-eye laxity

Given that the skin around the eyes is thinner and more sensitive, this region is more vulnerable to wrinkles, dark circles and laxity. With PRF treatment, the bags under the eyes “fill in” and fine lines and wrinkles are significantly reduced. 

4.    Improves skin texture and smooths out acne scars

PRF treatment increases skin moisture level, enhances the production of elastin, promotes blood circulation and protects skin from photoaging. All these contribute to skin rejuvenation, improve skin tone and reduce the occurrence of scars.

5.    Holistically contributes to a more youthful facial look

PRF treatment stimulates the production of proteins and growth factors that ensure improved texture, enhanced volume and the prevention of skin discoloration. With the suitable, personalized session repetition rate, it ensures an overall youthful skin at the areas where it is applied.
PRP - PRF
PRF filler: to enhance firmness & restore volume loss
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What is PRF filler? Since we have prepared PRF we can treat it thermally at a special chamber to change its composition and bring it in a filler form, similar to that of hyaluronic acid.

What does it offer? The same as hyaluronic acid fillers; that’s why it is used to restore volume loss, smooth out wrinkles and fine lines, etc. PRF filler has exceptional effects in reducing dark circles, due to the decrease in volume under the eyes.

How is it performed/applied? Just like fillers, either with a needle or with a cannula

How is it different from synthetic fillers? It offers more natural effect, it is made from your own blood, so hypersensitivity/allergy is excluded, and no heterologous product is used. It improves tissue texture and, in contrast with hyaluronic acid, in contrast to hyaluronic acid, it cannot result in deformations in the event of excess administration. Moreover, when applied to sensitive areas (e.g. the lower eyelids) it does not cause the Tyndall Effect, namely PRF does not “take” a whitish or grey hue in the tissues, which may happen when applying hyaluronic acid.
It is worth clarifying, though, that PRF filler falls short in duration of effects, as well as in supportive capacity compared to hyaluronic acid. 

Who is the ideal patient for a PRF filler? Young and middle-aged people, with minor problems (slight decrease in volume, shallow wrinkles) are the ideal candidates.

How often should it be repeated? Depending on the facial area, about every 4-9 months.
FAQ


PRF is prepared from the patient’s blood, while during the processing to obtain PRF, no other substances (e.g. anticoagulant agents, activators, etc.) are added; thus, the chances of an allergic reaction are zero. When prepared and applied by highly skilled professionals, it works miracles with no side effects. After the treatment, what might occur is mild edema at the blisters, skin sensitivity, and local minor bruise.

PRF is mainly applied on the face, the neck and the neckline. It can also be used on the entire body, when scars of any etiology, stretch marks, marks tec., require treatment.

As already mentioned above, platelets are the source of many growth factors (TGF-β, VEGF,EFG,IGF-1,TNF-a etc.). Growth factors play a major role in regenerative-healing processes of the body.
They stimulate the proliferation cells, promoting the development of new tissues and the repair of damaged ones.
They accelerate the healing process of wounds, by attracting repair cells in the area and promoting the formation of new blood vessels.
They contribute to the regeneration of various tissue types, the bones, the cartilages, the muscles and the skin included.
They promote the formation of new blood vessels, by improving blood circulation and tissue oxygenation.
Finally, some growth factors have anti-inflammatory properties and help reduce edema and pain. So, it’s not hard to realize the important properties of PRF treatment in skin regeneration and deep rejuvenation.
Christos Krasadakis, co-founder of Face of Athens, is an opinion leader worldwide, as regards the application of PRF platelet concentrates, due to his extremely close cooperation with Richard Miron, the top researcher in the world in this field.
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Frequently asked questions, How it is performed, Personal experiences, Before / After
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